Tencent Hy4 Preview Helps Optimize GPCR Membrane Simulation, 2x Speedup Reported

Key Info

A computational researcher reports that Tencent's Hy4 preview model helped them optimize a lipid bilayer simulation for GPCR ligand screening, reaching 54.9 ms/step — roughly 2x faster than their previous baseline.

Highlights

• The workload required building a stable phospholipid bilayer of over 30,000 atoms with an SO3LR machine learning force field and a heavily customized JAX implementation.
• Manual hot-path refactors kept failing to align or speed up, and overseas models were not allowed in the organization.
• Switching to Hy4 preview finally made the optimization work, with about 2x speedup over the baseline; the user says it helped them hit a deadline and called it a life-saver.